Innovations in synthesis of bioactive small molecules
July 2019
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Welcome! We are synthetic organic chemists with research interests in catalysis, synthetic methodology, total synthesis, and medicinal chemistry. The primary goal of our research program is to enable the efficient synthesis of complex molecules, thereby expanding the diversity of chemical structures that can be pursued as drug leads. In this way, we are working towards eliminating synthetic considerations as a barrier to the discovery of new therapeutics.
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Recent News
- July 2020 - Mike has been promoted to Associate Professor with tenure!
- July 2020 - New postdoc Jared Lowe joins the lab. Jared recently completed his PhD at UNC Chapel Hill under the supervision of Prof. Gagné.
- March 2020 - Julie won a poster prize at the Florida Heterocyclic and Synthetic Conference at the University of Florida. Congratulations!
- December 2019 - Our first manuscript arising from a collaboration with the Gutierrez lab at the University of Maryland has been published in ACS Catalysis. Some great insights into the mechanism of iminium salt-catalyzed C-H amination. Check it out on our publications page!
- October 2019 - Julie and Logan's manuscript on scandium triflate-promoted nitrene-transfer {5 + 1] cyloadditions has been published in Organic & Biomolecular Chemistry. Congratulations!
- June 2019 - Freddie's manuscript on organocatalytic aziridination has been published in The Journal of Organic Chemistry. Congratulations!
- May 2019 - Logan has successfully defended his Ph.D. dissertation will start a postdoctoral position soon in the Stephenson lab at the University of Michigan. Congratulations and good luck!
- May 2019 - Congratulations to second-year undergraduate Muyuan Wang, who was awarded a Bass Undegraduate Research Scholarship to fund research over the summer.
- April 2019 - Julie won second place in the 3rd-year PhD student poster session. Awesome job Julie!
- April 2019 - Mike has received an NSF CAREER award!
- March 2019 - Logan, Freddie, and Julie's nitrene-transfer [5 + 1] cycloaddition has been published in Organic Letters. Congratulations!
- November 2018 - Mike has been awarded a 2019 Thieme Chemistry Journals Award! Thank you to the editorial boards of Synlett, Synthesis, and Synfacts for the honor.
- November 2018 - First-year Ph.D. student Carrick Clark-Cearley joins the lab. Welcome!
- July 2018 - Congratulations to our first Ph.D., William Shuler! Best of luck in the Krische lab!
- June 2018 - Check out our invited Synpacts article on organocatalytic C–H oxidation that just appeared in Synlett.
- March 2018 - Rob and Philip's N-heteroarene oxidation work has been published in Organic Letters. Congratulations!
- January 2018 - The lab (along with collaborators) has received a grant from the Ivy Biomedical Innovation fund to research new treatments for glioblastoma.
- December 2017 - Logan, Balaram, and Daoyong's work on site-selective organocatalytic C–H amination has been published in Chemical Science. Congratulations!